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. 2007 Jul 10;35(14):4858–4868. doi: 10.1093/nar/gkm492

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© 2007 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — The INS1 cell line responds to both an LXR agonist and glucose. (A) INS1 cells were treated with 2 μM of the GW3965 LXR agonist for 24 h and the effect on the endogenous expression of known LXR target genes as well as genes involved in insulin signaling analyzed by qPCR. The endogenous expression of the pyruvate kinase (B) and LXRβ (C) in INS1 cell treated with various concentrations of glucose was measured by qPCR. The relative fold change of the GW3965 or the glucose treatments was compared to the DMSO treatment (A) or 3 (mM) glucose (B and C), respectively, the values of which were set to 1.0 ±SEM. *Indicates P < 0.05 and **Indicates P < 0.001 using the student t-test.