Figure 2.

Schematic representation of Shigella pathogenesis. The invasion of the intestinal mucosal cells by S. flexneri is regulated by a number of virulence factors, including the transcriptional regulator, VirF. The VirF protein then activates the transcription of downstream virulence factors under the proper environmental conditions for invasion. Durand and colleagues (35) have shown that TGT is linked to the efficient translation of the VirF protein. Figure adapted from one provided by Prof. Ruth Brenk, University of Dundee.