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Scheme of Notch signaling. (A) Ligands of the Delta (Dll) or Jagged (Jag) family induce intramembrane cleavage of the Notch receptor. The intracellular domain replaces transcriptional corepressors with activators enabling transcription of Hes and Hey genes by RBPJκ. (B) Domain organization of Hes and Hey proteins. Numbers indicate the amino acid content of the individual protein domains.
