Table 1.
Phenotypes of Hes or Hey gene deficient mice
| Notch regulated | Mouse knockout phenotype | References | |
|---|---|---|---|
| Hes1 | Yes | Neurulation defects, premature differentiation of neural progenitor cells | (120–122) |
| Eye and inner ear defects | (123–125) | ||
| Pancreas defects and defective endocrine differentiation | (126) | ||
| Disturbed T-cell differentiation, lack of thymus | (127) | ||
| Hes3 | No | Viable, fertile | (128) |
| Hes5 | Yes | Viable, fertile | (35,121) |
| Eye and inner ear defects | (129,104) | ||
| Elevated myelin levels in central nervous system | (117) | ||
| Hes6 | No | Viable, fertile | (24) |
| Hes7 | Yes | Somitogenesis defects | (108) |
| Hes1/5 | Enhancement of Hes1−/− phenotype | (35,121,125,130) | |
| Defects in cranial and spinal nerves | (131) | ||
| Hes1/3 | Missing midbrain and anterior hindbrain due to premature neuronal differentiation | (128) | |
| Hes1/3/5 | More severe than Hes1/5 loss | (125) | |
| Hey1 | Yes | Viable, fertile | (132,133) |
| Hey2 | Yes | Congenital heart defects | (134–138) |
| Decreased arterial neointima formation | (87) | ||
| HeyL | Yes | Viable, fertile | (47) |
| Hey1/2 | Angiogenesis and arterial differentiation defects | (132,133) | |
| Hey1/L | Congenital heart defects | (47) |