Table 4. Associations between IL23R SNP rs1004819 genotypes and CD disease characteristics in the subcohort of the Munich IBD center (n = 457) for which detailed phenotypic data based on the Montreal classification [40] were available.
| IL23R rs1004819 genotype status | (1) CC | (2) CT | (3) TT | (1) vs. (2) p value | (1) vs. (3) p value | (2) vs. (3) p value |
| (n = 457) | (n = 193) | (n = 205) | (n = 59) | |||
| Male sex (n = 457) | 48.7% | 45.9% | 39.0% | 0.616 | 0.233 | 0.375 |
| Age at Diagnosis (yr) (n = 413) | ||||||
| Mean±SD | 27.3±12.5 | 28.5±14.5 | 28.1±15.8 | 0.297 | 0.697 | 0.833 |
| Range | 11–65 | 11–71 | 7–71 | |||
| Disease duration (yr) (n = 413) | ||||||
| Mean±SD | 11.9±8.6 | 12.0±8.6 | 13.4±10.7 | 0.889 | 0.476 | 0.515 |
| Range | 2–35 | 0–33 | 3–44 | |||
| Age at diagnosis (n = 413) | ||||||
| ≤16 years (A1) | 12.8% | 8.3% | 13.5% | 0.175 | 1.000 | 0.284 |
| 17–40 years (A2) | 76.7% | 76.2% | 71.2% | 1.000 | 0.465 | 0.460 |
| >40 years (A3) | 10.6% | 15.5% | 15.4% | 0.211 | 0.334 | 1.000 |
| Location (n = 451) | ||||||
| Terminal ileum (L1) | 12.0% | 13.4% | 13.6% | 0.762 | 0.821 | 1.000 |
| Colon (L2) | 21.5% | 16.4% | 6.8% | 0.245 | 0.011,OR 0.27 CI 0.09–0.78 | 0.080 |
| Ileocolon (L3) | 66.0% | 69.2% | 79.7% | 0.519 | 0.053 | 0.140 |
| Upper GI (L4) | 0.5% | 1.0% | 0.0% | 1.000 | 1.000 | 1.000 |
| Any ileal involvement (L1+L3) | 76.4% | 82.6% | 93.2% | 0.135 | 0.004,OR 4.24 CI 1.46–12.34 | 0.060 |
| Behaviour 1 (n = 452) | ||||||
| Non-stricturing, Non-penetrat. (B1) | 22.5% | 21.3% | 18.6% | 0.808 | 0.591 | 0.719 |
| Stricturing (B2) | 26.2% | 22.3% | 35.6% | 0.410 | 0.187 | 0.043, OR 1.93 CI 1.03–3.61 |
| Penetrating (B3) | 51.3% | 56.4% | 45.8% | 0.313 | 0.552 | 0.181 |
| Surgery because of CD 3 (n = 441) | 48.1% | 50.3% | 62.7% | 0.683 | 0.054 | 0.103 |
| Fistulas (n = 455) | 50.8% | 56.3% | 45.8% | 0.314 | 0.553 | 0.183 |
| Stenosis (n = 457) | 59.6% | 59.6% | 74.6% | 0.607 | 0.045,OR 1.99 CI 1.04–3.82 | 0.090 |
Significant P-values are given in bold letters including corresponding odds ratios (OR) and 95% confidence intervals (CI). However, none of these P-values remained significant after Bonferroni correction (P>0.05). For each variable, the number of patients with a complete data set is given. Footnotes: See legend of Table 3 for detailed explanation.