Table 2.
Effect of intrastriatal infusion with c-fos antisense and sense oligonucleotides on pallidal extracellular GABA levels in the awake freely moving rat
| Treatment, nmol | Baseline, nM | n | ↓Time, min
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| −60 | −30 | 0 | 30 | 60 | 90 | 120 | 150 | 180 | 210 | |||
| Ringer | 9.5 ± 0.7 | 5 | 96 ± 2 | 98 ± 3 | 118 ± 13 | 95 ± 5 | 92 ± 11 | 88 ± 11 | 90 ± 13 | 100 ± 17 | 108 ± 16 | 109 ± 17 |
| Antisense | 9.8 ± 1 | 7 | 95 ± 7 | 98 ± 3 | 87 ± 3 | 103 ± 5 | 101 ± 7 | 107 ± 8 | 102 ± 6 | 102 ± 8 | 91 ± 5 | 101 ± 10 |
| Sense | 9.6 ± 0.2 | 5 | 110 ± 12 | 85 ± 7 | 102 ± 5 | 100 ± 7 | 99 ± 8 | 113 ± 9 | 114 ± 9 | 112 ± 8 | 106 ± 7 | 102 ± 7 |
Rats were injected with c-fos antisense or sense oligonucleotides. The sham group was injected with Ringer solution alone. The vertical arrow indicates the injection time. The results are expressed as a percentage of three basal values measured prior to the oligonucleotide infusion. Statistical analysis was performed by Student’s paired t test and two-way ANOVA followed by Newman–Keuls test for multiple comparisons.