Figure 2.

Day–night expression profiles of CREM, NAT and Fra-2 in the mouse and rat are identical. (A–C) Pineal RNA was extracted from mice sacrificed at the times indicated above the lanes and assayed for CREM, Fra-2, and NAT expression. (D) Rat RNA was extracted at the same time points and assayed for NAT mRNA. Both mice and rats were housed for 2 weeks prior to analysis in light/dark 12:12 lighting conditions (night from 19:00 to 07:00) as indicated by the black and white bar above the panels.