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. 2007 Jul 26;7:139. doi: 10.1186/1471-2407-7-139

Figure 3.

Figure 3

HIF2α reduces cell proliferation. a) In vitro proliferation assay reveals a reduction in the relative cell proliferation rate of HIF2α expressing cells (E1 and E2) as compared to control cells (NT), while N1E-115 cells transfected with HIF2α(1–485) display an accelerated proliferation (DN5 and DN8). Data are mean ± SEM of 4 independent experiments and reported to 100% for control untransfected cells. *: Significant. b) Western blot analysis reveals an increased in p42/44 MAP kinase phosphorylation in proliferating clones (DN5 and DN8) while the opposite effect is observed in clones displaying a low growth rate (E1 and E2).