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HIF2α modulates the in vivo growth of neuroblastomas. The volume of tumour nodules was measured every 2 days after injection of control cells, HIF2α or HIF2α(1–485) transfected cells. Data are mean ± SEM of 15 untransfected tumours (NT), 16 pCDNA3.1-transfected tumours, 18 HIF2α tumours (E1 (n = 9) and E2 (n = 9)), and 16 HIF2α(1–485) tumours (DN5 (n = 9) and DN8 (n = 7)). Each tumour corresponds to one injection in one mouse.
