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KI-IOVs from ld/ld mice do not bind ankyrin. KI-IOVs (30 μg/ml) were incubated for 3 h on ice with increasing amounts of D3/D4 125I-ankyrin (a) or intact 125I-ankyrin (b). Membranes were pelleted, washed, and assayed in γ counter for radioactive ankyrin (n = 5). The resulting graph is a plot with subtracted heat-denatured controls. Mutant mice KI-IOVs exhibit negligible binding to either the D3/D4 ankyrin fragment of full-length ankyrin.
