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Flow Cytometric Endpoints
| Endpoint | Measure of |
|---|---|
| Micronucleus frequency | DNA double-strand breaks and/or chromosome lag |
| EMA-negative nuclei : bead ratio | Cytotoxicity (relative survival) |
| EMA-positive event frequency | Cytotoxicity (apopotosis and/or necrosis) |
| Perturbations to SYTOX fluorescence | Cytotoxicity (cell cycle effects) |
| Hypodiploid nuclei frequency | Aneuploidization (although apoptosis can not be ruled out) |
Abbreviations: EMA = ethidium monoazide bromide
