Figure 3.
Chronic DHEA (1%) treatment reverses chronic hypoxia-induced increases in mean pulmonary artery pressure (MPAP: A), ratio of right ventricle to left ventricle + septum weights (RV/LV+S: D), % pulmonary artery wall thickness (%WT: E, 50-100 μm in diameter) without effects on mean systemic pressure (MSAP: B) and cardiac index (CI: C). Dashed lines indicate normal values of low altitude untreated rats from the prevention study. Values are means ± SE of n=7 for 0% DHEA-treated (0% DHEA) and 6 for 1% DHEA-treated (1% DHEA) groups, except for CI which was measured in 5 (0% DHEA) and 3 rats (1% DHEA); * P < 0.05 vs. 0% DHEA.