Table 2. Association between Haplotype/SNP and MTCT.
| Haplotype/SNP | Carrier Status* | All Eligible Births N (%) | MTCT Births N (%) | RR (95% CI)† |
| A | − − | 308 (56.3) | 54 (53.5) | 1.12 (0.78, 1.59) |
| ++/+− | 239 (43.7) | 47 (46.5) | ||
| B | − − | 526 (96.2) | 94 (93.1) | 1.96 (1.05, 3.66) |
| ++/+− | 21 (3.8) | 7 (6.9) | ||
| C | − − | 441 (80.6) | 86 (85.2) | 0.72 (0.43, 1.20) |
| ++/+− | 106 (19.4) | 15 (14.8) | ||
| D | − − | 363 (66.4) | 62 (61.4) | 1.24 (0.86, 1.77) |
| ++/+− | 184 (33.6) | 39 (38.6) | ||
| E | − − | 387 (70.8) | 72 (71.3) | 0.97 (0.66, 1.43) |
| ++/+− | 160 (29.2) | 29 (28.7) | ||
| F1 | − − | 500 (91.4) | 96 (95.1) | 0.55 (0.24, 1.30) |
| ++/+− | 47 (8.6) | 5 (4.9) | ||
| F2 | − − | 362 (66.2) | 68 (67.3) | 0.95 (0.66, 1.39) |
| ++/+− | 185 (33.8) | 33 (32.7) | ||
| G1 | − − | 488 (89.2) | 93 (92.1) | 0.71 (0.36, 1.39) |
| ++/+− | 59 (10.8) | 8 (7.9) | ||
| CCR2-64V→I | − − | 366 (66.2) | 67 (66.3) | 1.00 (0.69, 1.45) |
| ++/+− | 187 (33.8) | 34 (33.7) | ||
| CCR5-2733A→G | − − | 488 (89.0) | 93 (92.1) | 0.70 (0.36, 1.36) |
| ++/+− | 60 (11.0) | 8 (7.9) | ||
| CCR5-2554G→T | − − | 255 (46.5) | 43 (42.6) | 1.18 (0.82, 1.68) |
| ++/+− | 293 (53.5) | 58 (57.4) | ||
| CCR5-2459A→G | − − | 160 (29.2) | 35 (34.7) | 0.78 (0.54, 1.12) |
| ++/+− | 388 (70.8) | 66 (65.3) | ||
| CCR5-2135C→T | − − | 161 (29.3) | 35 (34.7) | 0.78 (0.54, 1.13) |
| ++/+− | 388 (70.7) | 66 (65.3) | ||
| CCR5-2132C→T | − − | 362 (65.9) | 61 (60.4) | 1.27 (0.89, 1.81) |
| ++/+− | 187 (34.1) | 40 (39.6) | ||
| CCR5-2086A→G | − − | 444 (80.7) | 86 (85.1) | 0.73 (0.44, 1.21) |
| ++/+− | 106 (19.3) | 15 (14.9) | ||
| CCR5-1835C→T | − − | 325 (59.1) | 64 (63.4) | 0.84 (0.58, 1.21) |
| ++/+− | 225 (40.9) | 37 (36.6) |
*
Non carriers of the haplotype or SNP were denoted as − − and carriers as ++/+−.
†
The risk ratio (RR) was calculated from log linear regression, where non carriers (− −) were the referent. Maternal CD4 count, maternal age, and mode of delivery were not significantly associated with the SNPs/haplotypes or MTCT. Maternal viral load was significantly associated with MTCT but was not associated with SNPs or haplotypes. Therefore, these covariates were not included as confounders in the regression models.