Table 5. Sensitivity analyses for SNP association with MTCT at different time points of follow-up.
SNP | Model | Birth RR (95% CI)† | 6 weeks RR (95% CI) | 12 weeks RR (95% CI) | Cumulative RR (95% CI) |
CCR5-2459A→G | Overall | 0.76 (0.44, 1.31) | 0.93 (0.61, 1.44) | 0.70 (0.47, 1.04) | 1.00 (0.69, 1.45) |
Low MVL | 0.14 (0.04, 0.51) | 0.38 (0.14, 1.00) | 0.29 (0.11, 0.80) | 0.70 (0.36, 1.36) | |
High MVL | 1.38 (0.61, 3.10) | 1.45 (0.78, 2.73) | 1.03 (0.60, 1.80) | 1.18 (0.82, 1.68) | |
CCR5-2135C→T | Overall | 0.76 (0.45, 1.32) | 0.94 (0.61, 1.45) | 0.70 (0.47, 1.05) | 0.78 (0.54, 1.12) |
Low MVL | 0.14 (0.03, 0.52) | 0.39 (0.15, 1.04) | 0.30 (0.11, 0.83) | 0.78 (0.54, 1.13) | |
High MVL | 1.38 (0.61, 3.10) | 1.46 (0.78, 2.73) | 1.03 (0.60, 1.80) | 1.27 (0.89, 1.81) |
The risk ratio (RR) was calculated from log linear regression, where non carriers (− −) were the referent.