Table 1. .

Summary of the Clinical Data Correlated with the Identified NOG Mutations^[Note]

	Incidence of Phenotype
	BDB
Mutation	Milda	Intermediateb	Severec	Distal SYM	Carpal Coalition	Shortened MC Id	Cutaneous Syndactyly
P35A	2/12	10/12			8/8	8/8	8/8
P35S		3/6	3/6		5/5e	5/5	4/6
A36P		4/4			2/2	0/2	0/4
E48K	2/4	2/4		+	2/2	2/2	0/4
R167G			2/2		1/2f	0/2	0/2
P187S	3/6	3/6		+	2/2	1/2g	6/6

Note.— All subjects had proximal SYM. Each hand of the patients was counted separately. Radiographs were not available for all affected individuals. For each of the listed features, the observed phenotypes refer to the total number of available data (as indicated after the slash).

^aDistal phalanges and nails present, but hypoplastic in fingers II–V.

^bAbsent distal and sometimes middle phalanges of fingers IV and/or V (more affected by BDB than are fingers II and III).

^cAbsent distal (and middle) phalanges of fingers II–V.

^dMC I=metacarpal bone I.

^eTwo of five are x-rays of a 6-mo-old child; both hands showed an accelerated carpal bone age of ∼2.5 years.

^fIn x-rays of a newborn, both hands showed an accelerated carpal bone age of ∼6 mo.

^gAdditionally shortened MC IV and V.