Figure  1. .

Autosomal dominant PCPSC in a six-generation family (Sk). A, Pedigree and haplotype analysis showing segregation of eight STR markers and two SNP markers on 20q, listed in descending order from the centromere. Squares and circles denote males and females, respectively. Filled symbols and bars denote affected status and haplotypes, respectively. Individual V:5 is marked with a question mark (?) to denote unknown status. Pedigree and haplotype data were managed using Cyrillic 2.1 software (FamilyGenetix). B, Slit-lamp image of lens from affected female V:12 (age 40 years) showing posterior subcapsular, nuclear, and anterior subcapsular opacities. C, Ideogram of chromosome 20, comparing the cytogenetic location of SNP markers defining the PCPSC locus in this study (red) with those of STR markers defining loci for CPP3 and PCZNC.^31,32