Figure 8. .

Histopathology and quantitative analyses of normal, Tr-J, and treated Tr-J sciatic nerves. A, Note the difference in morphology and mean axonal diameter of myelinated fibers in wild-type normal (a), Tr-J (b), curcumin-treated Tr-J (c), and placebo-treated Tr-J (d) sciatic nerves from 3-mo-old mice. Scale bars = 10 μm. B, Distribution of fiber size (based on diameter) in Tr-J (red), curcumin-treated Tr-J (white), and wild-type control (blue) mice. C, Distribution of axonal size in Tr-J (red), curcumin-treated Tr-J (white), and wild-type control (blue) mice. D, Normalized plot of g ratios within each group, to account for the trends (nonlinear) between axon size and the ratio observed in the wild-type mice.