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Time course of sympathetic fiber (TH-IR positive) sprouting in L4 DRG after SNI compared to sham-treated animals. A, No TH-IR is detectable after sham surgery. B, 4 weeks after SNI, TH-IR positive fibers co-mingle with spinal nerve fibers in the vicinity of DRG and penetrate into the DRG. C, D, 8 weeks after surgery, TH-IR positive fibers are present in the DRG and surround some DRG neurons, scale bar 25 μm.
