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Sequences at breakage–fusion junctions. (A) Example of putative homologous recombination based repair with extended microhomology; (B) example of nonhomologous end joining showing 5-bp overlapping microhomology; (C) example of nonhomologous end joining including putative nontemplated DNA synthesis. In each example, the BAC sequence is shown in the middle with the genomic sequences contributing to the rearrangement shown above and below. Regions of sequence identity are highlighted.
