Figure C1. .

Inference of LOH on the basis of heterozygous SNP calls. A–C, The schema of determination of LOH blocks in inference of LOH. D, ROC curve for LOH determination. The sensitivity and specificity of LOH detection for pure tumor specimens were plotted for varying thresholds of Z(Ω) for LOH determination, where SNPs that were heterozygous in the paired LCL sample and were homozygous in the tumor sample were considered to be truly positive for LOH and SNPs that were heterozygous in both the paired LCL and tumor sample were considered to be truly negative.