Table 1. .
Two-Point LOD Scores for Microsatellites in the Candidate Region at 15q22–15q25[Note]
| LOD at θ = |
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| Marker | Genetic Distancea | .00 | .01 | .05 | .10 | .20 | .30 | .40 | Zmax | θmax |
| D15S153 | 62.40 | 5.43 | 6.49 | 6.92 | 6.65 | 5.50 | 3.91 | 1.99 | 6.92 | .05 |
| D15S988 | 66.90 | .93 | 1.67 | 2.09 | 2.09 | 1.75 | 1.22 | .55 | 2.11 | .07 |
| D15S216 | 70.73 | 7.99 | 7.86 | 7.33 | 6.63 | 5.13 | 3.47 | 1.66 | 7.99 | .00 |
| D15S131 | 71.28 | 8.59 | 8.47 | 7.96 | 7.29 | 5.77 | 4.04 | 2.05 | 8.59 | .00 |
| D15S1050 | 71.82 | 9.71 | 9.55 | 8.90 | 8.05 | 6.21 | 4.18 | 1.97 | 9.71 | .00 |
| D15S204 | 71.82 | 9.24 | 9.09 | 8.48 | 7.69 | 5.97 | 4.05 | 1.91 | 9.24 | .00 |
| D15S188 | 71.82 | 7.41 | 7.29 | 6.83 | 6.23 | 4.92 | 3.46 | 1.82 | 7.41 | .00 |
| D15S1023 | 74.69 | 3.44 | 5.18 | 6.21 | 6.21 | 5.30 | 3.83 | 1.97 | 6.28 | .07 |
| D15S205 | 78.92 | −0.46 | 1.67 | 3.33 | 3.77 | 3.50 | 2.60 | 1.33 | 3.80 | .12 |
Note.— The markers D15S153, D15S131, and D15S205 originate from the ABI Prism Linkage Mapping Set (MD-10 v2.5, Applied Biosystems). Marker D15S131 generated the highest LOD score in a total genome scan (data not shown). Recombination events between D15S988 and D15S216 and between D15S188 and D15S1023 defined a candidate region of 7.79 cM. The maximum LOD score (Zmax) was obtained for D15S1050, as indicated in bold. The NR2E3 gene is located between D15S1050 and D15S204. LOD score calculations were performed on all available family members.
a
According to the Marshfield map (NCBI Map Viewer).