Table 2. .

SIFT and PolyPhen Prediction of Amino Acid Polymorphisms

	AA			Prediction
Position	Ancestral	Derived	Frequency of Derived Allele (%)	PolyPhen	SIFT	Location
914	P	L	63	Damaging	Tolerated	Extracellular
1091	N	S	34	Benign	Tolerated	Extracellular
992	T	P	33	Benign	Tolerated	Extracellular
1147	I	M	15	Benign	Damaging	GPS unit, extracellular
993	V	A	8	Benign	Tolerated	Extracellular
528	R	E	3	Benign	Tolerated	REJ module, extracellular
1729	V	I	2	Benign	Tolerated	Transmembrane, extracellular
447	R	G	1	Benign	Tolerated	REJ module, extracellular