Figure 2.
Gene expression of six Aβ-producing and -metabolizing enzymes in the choroid plexus, brain capillaries that comprise the BBB, and the surrounding brain parenchyma. Values are mean ± SEM (n=3). Significant differences are noted by: *different from choroid plexus by one-way ANOVA with Newman-Keuls post hoc test, $different from choroid plexus by t-test, #different from capillary endothelium of the striatum. Abbreviations: APP: amyloid precursor protein; ECE-1 endothelin converting enzyme-1; IDE: insulin degrading enzyme; HP: hippocampus; ST: striatum; FC: frontal cortex; CB: cerebellum; CE: capillary endothelium; BP: brain parenchyma. Note the differences in the values of the y-axes.