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. 2007 Aug 24;3(8):e117. doi: 10.1371/journal.ppat.0030117

Figure 3. Sensitivity of Parental, Mutant, and Adapted Envs to Neutralization by HIV Patient Sera.

Figure 3

(A–D) Serum from four HIV-infected individuals who were not on antiretroviral therapy and had CD4 counts >400 were tested for neutralization activity by limiting dilution. Virus pseudotypes bearing the indicated Env were incubated with serial dilutions of patient sera for 1 h, added to 293.CD4.CCR5 cells, and the amount of luciferase activity measured 3 d later. The amount of luciferase activity obtained for each virus pseudotype in the absence of serum was set to 100%. The results shown are the average for three or four independent experiments, ± standard error of the mean.