Figure 2. Location Features Encoding Protein Disorder for Molecular Function (A) Categories and Biological Process (B) Categories That Are Enriched in Disordered Proteins.

The locations are represented on the x-axis from N terminus through equally proportioned mid segments S1–S8 to C terminus. The clustering of GO categories was performed using Ward's hierarchical clustering method [30]. The heatmap colours reflect the significance of the association between the frequency of disordered residues within the location region and the GO category. Red blocks indicate that a high average frequency of disordered residues is associated with the GO category and the location region. Blue blocks indicate an association between low average frequency of disordered residues in the location and GO category.