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SARS-CoV S protein-specific IFN-γ (A) and IL-4 (B) ELISPOT results. The numbers of IFN-γ-secreting cells in the spleens of mice harvested 10 days after the final immunization and stimulated in vitro with the S protein are shown. The results represent the averages for triplicate wells for three mice and are expressed as means ± SDs.
