TABLE 1.
Group | Vaccine | Route of administration | Dose per mouse |
---|---|---|---|
1 | pcDNA-S | i.m. | 200 μg |
2 | pcDNA-S + pcDNA-IL-2 | i.m. | 200 + 50 μg |
3 | pcDNA-S | i.e.a | 30 μg |
4 | pcDNA-S + pcDNA-IL-2 | i.e. | 30 + 8 μg |
5 | pcDNA-S | Oralb | 5 × 109 CFU |
6 | pcDNA-S + pcDNA-IL-2 | Oral | 5 × 109 CFU + 1 × 109 CFU |
7 | pcDNA3.1 | i.m. | 200 μg |
8 | pcDNA-IL-2 | i.m. | 200 μg |
9 | PBS | i.m. | 100 μl |
10 | pcDNA3.1 | Oral | 5 × 109 CFU |
11 | CS022 | Oral | 5 × 109 CFU |
i.e., electroporation.
Oral immunization with attenuated S. enterica serovar Typhimurium CS022.