TABLE 2.
Correlations between antibody activities in sera from MeNZB and MenBvac vaccinees measured by different antibody assays with the homologous and heterologous vaccine strainsa
| Antibody assaysb | Spearman rank order correlations coefficient
|
|||
|---|---|---|---|---|
| Homologous strains
|
Heterologous strains
|
|||
| MeNZB groupc | MenBvac groupd | MeNZB groupc | MenBvac groupd | |
| IgG OMV ELISA vs IgG ELISA with live bacteria | 0.883 | 0.881 | 0.801 | 0.938 |
| IgG OMV ELISA vs SBA assay | 0.797 | 0.837 | 0.676 | 0.819 |
| IgG OMV ELISA vs OPA assay | 0.836 | 0.895 | 0.851 | 0.912 |
| IgG OMV ELISA vs total IgG band intensity on blots | 0.757 | 0.833 | 0.585 | 0.855 |
| IgG with live bacteria vs total IgG band intensity on blots | 0.615 | 0.901 | 0.474 | 0.788 |
| IgG with live bacteria vs OPA assay | 0.850 | 0.902 | 0.819 | 0.907 |
| SBA assay vs IgG ELISA with live bacteria | 0.902 | 0.851 | 0.799 | 0.797 |
| SBA assay vs OPA assay | 0.835 | 0.799 | 0.726 | 0.843 |
a
All correlations were significant (P < 0.001).
b
OMVs were the antigens in the ELISA and the immunoblotting assay; live meningococci were used in the remaining assays.
c
Pre- and postvaccination sera from 24 individuals.
d
Pre- and postvaccination sera from 26 individuals in all assays except for the blotting assay, which had 16 individuals.