TABLE 1.
Pretreatment median values of CSF WBC count, IgMIF, CSF IgM concentration, CSF LATEX/IgM end titer, CSF IL-10 concentration, CSF total protein concentration, and serum IgM and IL-10 concentrations in cured and relapsed patients with hemolymphatic-stage sleeping sickness
| Parameter | Median value (interquartile range) for group
|
Pa | |
|---|---|---|---|
| Cured patients (n = 46) | Relapsed patients (n = 14) | ||
| CSF WBC count (no. of cells/μl) | 2 (1-3) | 3 (1-4) | 0.63 |
| IgMIF (%) | 0 (0-0)b | 50 (5-61)c | <0.0001 |
| CSF IgM concn (mg/liter) | 0.82 (0.48-1.79) | 3.33 (1.97-7.5) | 0.0005 |
| CSF LATEX/IgM test end titer | 0 (0-2) | 2 (2-8) | 0.0003 |
| CSF IL-10 concn (pg/ml) | 5.7 (1.9-7.4) | 8.3 (5.2-14.7) | 0.022 |
| CSF total protein (mg/liter) | 344 (291-401) | 318 (293-402) | 0.88 |
| Serum IgM concn (g/liter) | 4.53 (2.48-7.5)b | 5.13 (2.76-8.5)c | 0.59 |
| Serum IL-10 concn (pg/ml) | 90 (45-139)b | 124 (93-136)c | 0.14 |
a
Differences were tested by use of the Kruskal-Wallis test.
b
n = 44.
c
n = 13.