FIG. 5.
Pathology of invasion of E. histolytica in human intestinal xenografts. Sections of intestinal xenografts of human colon in SCID mice 24 h following luminal injection of 1 × 106 Entamoeba histolytica (HM1) trophozoites are shown. (Left) Acute inflammatory infiltrate and undermining of the mucosa in infected xenografts. The lumen is filled with proteinaceous debris and clumps of trophozoites (closed arrows). Neutrophils (mouse) are shown with open arrowheads. (Right) Xenografts from mice treated with the cysteine proteinase inhibitor WRR483 showed no evidence of invasion (hematoxylin and eosin stain).