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Fab of the transmission-blocking MAb 2A8 bound by its heavy chain (H; blue) to the B loop (B; green) of domain 2 of Pvs25 (D2; green). The light chain of 2A8 Fab (L; gray) does not contact Pvs25, appearing to play no role in direct binding. The Pvs25 triangular prism is formed by domain 1 (D1; cyan), domain 2 (D2; green), domain 3 (D3; red), and domain 4 (D4; gold) (PDB accession code 1Z3G). (Reprinted from reference 42 with permission of the publisher).
