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Hypothetical model for the contacts between Candida telomerase components, based on the current analysis as well as prior studies with S. cerevisiae. Est1p has been demonstrated to bind telomerase RNA, while Est3p is known to require Est2p for RNA association. In light of the mutual dependence of Est1p and Est3p in telomerase association, we propose that Est1p contacts both Est3p and TER, while Est3p contacts both Est1p and Est2p.
