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. 2007 May 16;81(15):8180–8191. doi: 10.1128/JVI.00421-07

FIG. 7.

FIG. 7.

Activation of CD8 T cells in response to HIV-1-derived TLR ligands. Upregulation of CD69 on CD8+ T cells after 6 h of stimulation with HIV-1-derived oligonucleotides. No activation was observed after incubation with the corresponding U-to-A variants or after coincubation with chloroquine. Chloroquine did not suppress the activation induced by PMA-ionomycin (PMA+I). (A) Stimulation of PBMC with two representative HIV-1-derived oligonucleotides, as well as their corresponding U-to-A variants. (B) Mean percentages ± standard deviations of CD69+ CD8+ T cells following incubation with these nine novel HIV-1-derived oligonucleotides and their corresponding U-to-A variants and after coincubation of the oligonucleotides with chloroquine in five independent experiments. RNA40, GCCCGUCUGUUGUGUCACUC; Poly U, UUUUUUUUUUUUUUUUUUUU.