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Coreceptor use of viral env populations. Infection of CCR5-and CXCR4-expressing cells is indicated by open circles and crosses, respectively. Infection was measured by luciferase activity (in RLU) produced in cell culture. Samples are grouped by subtype (A, D, and A/D recombinant; n = 33, 25, and 10, respectively). The horizontal dotted line indicates 200 RLU, the threshold for defining CXCR4 use in this study. The median RLU of each group is indicated by horizontal bars.
