TABLE 1.

Potential signature genes for early (day 1 to day 3) stage of LCMV-WE infection

GenBank accession no.	Description	Gene symbol	Fold changea
NM_000647	Chemokine (C-C motif) receptor 2	CCR2	3.6
NM_000591	CD14 antigen	CD14	2.3
AF130095	Fibronectin 1	FN1	3.4
AI459194	Early growth response 1	EGR1	−3.2
NM_000399	Early growth response 2 (Krox-20 homolog, Drosophila)	EGR2	−13.3
NM_015714	Putative lymphocyte G0/G1 switch gene	G0S2	−3.2
NM_006018	G protein-coupled receptor 109B	GPR109B	−9.5
BE973687	Hairy and enhancer of split 1	HES1	−3.7
BE898861	Heterogeneous nuclear ribonucleoprotein C (C1/C2)	HNRPC	−3.1
BE256479	Heat shock 60-kDa protein 1 (chaperonin)	HSPD1	−3.1
AF073310	Insulin receptor substrate 2	IRS2	−4.0
AA348410	Inositol 1,4,5-trisphosphate 3-kinase B	ITPKB	−4.4
NM_002258	Killer cell lectin-like receptor subfamily B, member 1	KLRB1	−4.0
NM_005466	Mediator of RNA polymerase II transcription	MED6	−4.3
NM_018835	Membrane-associated DNA binding protein	MNAB	−3.0
AI935096	Nuclear receptor subfamily 4, group A, member 2	NR4A2	−6.8
NM_014059	Response gene to complement 32	RGC32	−4.9
AY151286	Prostaglandin-endoperoxide synthase 2	PTGS2	−24.5
AB051450	Transducer of ERBB2, 2	TOB2	−3.0
AK025862	Tumor rejection antigen (gp96) 1	TRA1	−3.7
Other	Otherb	71 genes	≥−2

^aGeometric means of the changes for days 1, 2, and 3 after infection. Mean changes in expression for four LCMV-WE-infected animals were compared to results from three LCMV-Arm-infected animals, and 91 genes had ANOVA P values of <0.05.

^bThe other 71 genes are listed elsewhere (see Table SV in the supplemental material).