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Correlation between level of transgene expression and severity of degeneration
| Line | Ratio of transgene to endogenous opsin mRNA | Severity of retinal degeneration measured by ERG a-wave amplitude,* μV |
|---|---|---|
| P347 C1 | 0.25:1 | 191 ± 88.6 (n = 7) |
| P347 A1 | 1:1 | 53 ± 9.0 (n = 9) |
| P347 C2 | 1:1 | 14 ± 12.0 (n = 6) |
| P347 A2 | 5:1 | 8 ± 6.6 (n = 4) |
| P347 E | 5:1 | 3 ± 1.4 (n = 4) |
Measurements were made at 30 days of age. The range for a-wave amplitudes in normal mice is 100–300 μV. Values are mean ± SD.
