FIG. 1.

AAV2 crystal structure. (A) Surface topology of the whole capsid, viewed down the icosahedral fivefold symmetry axis, that contains a pore (left) bounded by five symmetry-related Vp subunits shown in salmon, blue, green, purple, and cyan ribbons in the close-up view on the right. The depth-cued view (left) shows the tops of the three protrusions surrounding the icosahedral threefold axes in white and the rest of the capsid in red. (B) Top and (C) side views of the icosahedral fivefold-symmetry-related Vps (in the same colors as in panel A) with a close-up of the pore on the right. Leu336, located at the inside base of the pore, is highlighted in red in panels B and C.