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. 2007 Jun 6;81(16):8601–8612. doi: 10.1128/JVI.00608-07

FIG. 5.

FIG. 5.

Involvement of hCD81 in the infection of HCVpv and HCVrv. (A) Effect of anti-hCD81 antibody on the infectivity of HCVpv (gray-filled bars), HCVrv (black-filled bars), or VSVpv (open bars) in Huh7 cells. (B) Cell surface expression of hCD81 on Huh7 cells transfected with siRNA targeted to hCD81 or control siRNA was examined by FACS analysis after staining with anti-hCD81 antibody. (C) Effect of knockdown of hCD81 in Huh7 cells by siRNA targeted to hCD81 on the infection of HCVpv, HCVrv, or VSVpv. (D) Cell surface expression of hCD81 on HepG2 and HepCD81 cells was examined by FACS analysis after staining with anti-hCD81 antibody. (E) Infectivity of HCVpv, HCVrv, or VSVpv to HepG2 or HepCD81 cells and the effect of anti-hCD81 antibody on the infection of the viruses to HepCD81 cells. The results shown are from three independent assays, with the error bars representing the standard deviations.