TABLE 1.
Humoral immune response in SHIVSF162P3N-infected macaques
| RM | Protein | Antibody response at wpia:
|
|||
|---|---|---|---|---|---|
| 0 | 6 | 12 | 28 | ||
| BR24 | gp120 | − | − | − | − |
| gp41 | − | − | − | − | |
| p31 | − | − | − | − | |
| p27 | − | − | − | − | |
| CD80 | gp120 | − | ++++ | ++++ | ++++ |
| gp41 | − | ++++ | ++++ | +++ | |
| p31 | − | − | ++ | ++ | |
| p27 | − | ++++ | ++++ | +++ | |
| T799 | gp120 | − | ++++ | ++++ | ++++ |
| gp41 | − | ++++ | ++++ | +++ | |
| p31 | − | + | +++ | ++ | |
| p27 | − | ++++ | ++++ | ++ | |
a
SHIV-specific antibody responses were detected using the strip immunoblot assay in accordance with the manufacturer's instructions (Novartis, Emeryville, CA). Macaque sera reactivity was determined by comparison with two internal IgG strip controls. Scoring relative to level I and II control bands was as follows: −, an absent band; ±, intensity lower than the level I band; +, intensity equal to the level I band; ++, intensity greater than the level I but less than the level II band; +++, intensity equal to the level II band; ++++, intensity greater than the level II band.