TABLE 2.
Sequencing of adapted mutant 4 virus populations
| Clone | Adaptation mutationa
|
||
|---|---|---|---|
| [P17S] | [R35T] | Other | |
| 1 | − | − | [S28T] |
| 2 | + | − | − |
| 3 | − | [R35M]b | [L26F] |
| 4 | − | − | − |
| 5 | − | + | − |
| 6 | − | + | − |
| 7 | − | − | − |
| 8 | + | − | − |
| 9 | − | + | − |
| 10 | − | + | − |
| 11 | + | − | − |
| 12 | + | − | − |
| 13 | − | + | − |
| 14 | − | − | − |
| 15 | − | + | − |
| 16 | − | + | − |
a
The presence (+) or absence (−) of the indicated mutation in the clones is shown. All adaptation mutations are in 3A (see Fig. 3).
b
[R35M] is the predominant mutation in the coding region for 3A in the population of adapted mutant 5 viruses.