TABLE 3.
Sequencing of adapted mutant 5 virus populations
| Clone | Adaptation mutationa
|
|||
|---|---|---|---|---|
| [R35M]b | [D51G]c | Otherb | Otherc | |
| 1 | + | + | [L44S] | [F4S] |
| 2 | + | + | − | − |
| 3 | − | + | − | − |
| 4 | − | + | − | − |
| 5 | − | + | [E32G] | − |
| 6 | + | − | − | − |
| 7 | − | + | − | − |
| 8 | − | + | − | − |
| 9 | − | + | − | − |
| 10 | + | + | [D30G] | − |
| 11 | + | − | − | − |
| 12 | − | + | − | [M49T] |
| 13 | − | + | − | − |
| 14 | + | − | − | − |
| 15 | + | + | − | [V54A] |
| 16 | + | + | − | − |
| 17 | + | + | − | − |
| 18 | + | + | − | − |
| 19 | − | + | − | − |
| 20 | + | + | − | − |
| 21 | + | − | − | − |
| 22 | + | + | − | − |
| 23 | + | − | − | − |
a
The presence (+) or absence (−) of the indicated viral construct in the clones is shown.
b
Adaptation mutations in 3A (see Fig. 3).
c
Adaptation mutations in 3C.