FIG. 5.
IL-15-integrated vaccinia virus induces higher neutralizing antibody levels even in animals with preexisting vaccinia virus-neutralizing antibodies. Animals were first vaccinated with MVA (2 × 106 PFU) and boosted 10 weeks later with MVA or MVA-IL-15 (MVA15). Six months after the boosting serum, vaccinia virus-neutralizing antibody levels were determined in revaccinated animals by a plaque reduction assay, using serial dilutions (dil) of pooled sera from each group of five animals. The data shown are representative of three independent experiments. VAC, vaccinia virus.