TABLE 2.
Ability of sCD4 and broadly neutralizing antibodies to neutralize viruses from homosexual transmission couples for sCD4 and broadly neutralizing antibodies
| Virus varianta | No. of wks after seroconversion of recipient | IC50 (μg/ml)
|
||||
|---|---|---|---|---|---|---|
| sCD4 | b12 | 2G12 | 2F5 | 4E10 | ||
| D1.6F1 | −23 | >12.50 | 7.94 | 4.30 | 0.63 | 3.92 |
| D1.6G5 | 10.93 | 0.47 | >12.50 | <0.20 | 2.31 | |
| D1.6F3 | >12.50 | >12.50 | >12.50 | >12.50 | >12.50 | |
| R1.6F5 | 2 | >12.50 | >12.50 | >12.50 | >12.50 | >12.50 |
| R1.6G9 | >12.50 | >12.50 | >12.50 | 2.08 | 0.33 | |
| R1.48H8 | 452 | >12.50 | >12.50 | >12.50 | 8.90 | 0.28 |
| R1.48C4 | 5.92 | 0.74 | 0.41 | 0.34 | 0.58 | |
| R1.48D4 | 9.40 | >12.50 | 0.36 | 0.37 | <0.20 | |
| R1.48E1 | >12.50 | >12.50 | 0.39 | 2.31 | 6.23 | |
| D2.3A6 | 77 | >12.50 | 0.56 | >12.50 | 9.62 | 11.93 |
| D2.3B10 | >12.50 | >12.50 | >12.50 | 1.83 | >12.50 | |
| D2.3C3 | >12.50 | 1.87 | 3.70 | 2.10 | >12.50 | |
| D2.3D12 | >12.50 | >12.50 | 9.54 | 1.97 | >12.50 | |
| D2.3F4 | >12.50 | >12.50 | >12.50 | 2.61 | >12.50 | |
| R2.8A6 | 3 | >12.50 | 1.06 | >12.50 | 3.01 | <0.20 |
| R2.8D6 | >12.50 | 1.93 | >12.50 | >12.50 | >12.50 | |
| R2.8C6 | >12.50 | <0.20 | >12.50 | >12.50 | 6.86 | |
| R2.8D2 | >12.50 | <0.20 | >12.50 | >12.50 | 3.42 | |
| R2.8F6 | >12.50 | 0.25 | >12.50 | >12.50 | 0.31 | |
| R2.54G11 | 415 | >12.50 | >12.50 | 0.43 | 8.43 | >12.50 |
| R2.54H8 | >12.50 | >12.50 | 0.58 | 7.86 | 6.86 | |
| D3.14A5 | 0 | >12.50 | 0.89 | 0.32 | 2.55 | 2.92 |
| D3.14B2 | >12.50 | 0.68 | 0.58 | >12.50 | 1.60 | |
| D3.14E3 | >12.50 | 1.30 | 0.31 | 0.57 | 0.63 | |
| D3.14G1 | >12.50 | 0.50 | <0.20 | 0.60 | 4.12 | |
| R3.3A9 | 3 | >12.50 | >12.50 | >12.50 | >12.50 | 10.36 |
| R3.3D9 | >12.50 | >12.50 | >12.50 | >12.50 | >12.50 | |
| D4.3E9 | 102 | >12.50 | >12.50 | <0.20 | 11.08 | 1.12 |
| D4.3H4 | >12.50 | >12.50 | <0.20 | <0.20 | <0.20 | |
| D4.3H9 | >12.50 | >12.50 | <0.20 | 0.54 | 4.69 | |
| D4.5A11 | 126 | 11.65 | 0.53 | <0.20 | 2.17 | 5.21 |
| D4.5C8 | 7.84 | <0.20 | <0.20 | >12.50 | >12.50 | |
| D4.5F10 | >12.50 | <0.20 | <0.20 | <0.20 | 5.09 | |
| D4.5G3 | 12.33 | <0.20 | <0.20 | NDb | 1.90 | |
| D4.5H9 | 7.42 | <0.20 | <0.20 | ND | <0.20 | |
| R4.15A9 | 89 | >12.50 | >12.50 | >12.50 | >12.50 | >12.50 |
| R4.15D5 | >12.50 | >12.50 | >12.50 | >12.50 | >12.50 | |
| R4.15F10 | >12.50 | >12.50 | <0.20 | >12.50 | >12.50 | |
| R4.15F9 | >12.50 | 0.38 | >12.50 | >12.50 | >12.50 | |
| R4.15H6 | >12.50 | 1.08 | >12.50 | >12.50 | >12.50 | |
| R4.43A11 | 340 | >12.50 | 10.97 | 2.45 | >12.50 | 8.96 |
| R4.43B12 | >12.50 | >12.50 | >12.50 | >12.50 | >12.50 | |
| R4.43E1 | >12.50 | >12.50 | >12.50 | >12.50 | >12.50 | |
a
D, donor; R, recipient.
b
ND, not determined.