TABLE 3.
Sensitivity of viruses from parenteral transmission couples for sCD4 and broadly neutralizing antibodies
| Virus varianta | No. of mos after exposure | Core- ceptor use | IC50 (μg/ml)
|
||||
|---|---|---|---|---|---|---|---|
| sCD4 | b12 | 2G12 | 2F5 | 4E10 | |||
| D-H19296.D8 | −8 | >12.50 | >12.50 | >12.50 | >12.50 | 7.10 | |
| PD5.E5 | >12.50 | >12.50 | >12.50 | >12.50 | >12.50 | ||
| PD5.E8 | >12.50 | >12.50 | >12.50 | >12.50 | >12.50 | ||
| PD5.F2 | >12.50 | >12.50 | >12.50 | >12.50 | >12.50 | ||
| PD5.F3 | >12.50 | >12.50 | >12.50 | 9.70 | 6.70 | ||
| PD5.G5 | >12.50 | >12.50 | >12.50 | 11.60 | >12.50 | ||
| PD5.D6 | >12.50 | >12.50 | >12.50 | 4.10 | >12.50 | ||
| PD5.F7 | >12.50 | 3.40 | >12.50 | >12.50 | >12.50 | ||
| PD5.H11 | >12.50 | 9.60 | >12.50 | >12.50 | >12.50 | ||
| PR5.O4.A2 | 1.5 | 12.40 | <0.20 | >12.50 | >12.50 | >12.50 | |
| PR5.O4.A3 | >12.50 | 0.80 | >12.50 | >12.50 | >12.50 | ||
| PR5.O4.A5 | >12.50 | 1.20 | >12.50 | >12.50 | >12.50 | ||
| PR5.O4.B1 | 6.80 | 0.70 | >12.50 | >12.50 | >12.50 | ||
| PR5.O4.C7 | >12.50 | 1.50 | >12.50 | >12.50 | >12.50 | ||
| PR5.O4.D1 | >12.50 | 1.50 | >12.50 | >12.50 | >12.50 | ||
| PR5.O4.F4 | >12.50 | 0.80 | >12.50 | >12.50 | >12.50 | ||
| PR5.O8.B6 | 5.5 | 1.20 | 8.70 | >12.50 | >12.50 | >12.50 | |
| PR5.O8.C5 | 6.60 | 4.60 | >12.50 | >12.50 | >12.50 | ||
| PR5.O8.D4 | 2.40 | 6.20 | >12.50 | >12.50 | >12.50 | ||
| PR5.O8.F11 | >12.50 | 2.80 | >12.50 | >12.50 | >12.50 | ||
| PD6.A10 | 4.5 | R5 | >12.50 | 6.33 | >12.50 | 0.40 | 5.05 |
| PD6.C11 | R5 | >12.50 | 4.55 | 10.40 | 4.22 | <0.20 | |
| PD6.D9 | R5 | >12.50 | 5.92 | >12.50 | 6.97 | 0.83 | |
| PD6.E3 | R5 | >12.50 | 4.53 | >12.50 | 7.88 | 6.43 | |
| PD6.F11 | R5 | 3.62 | 0.63 | ND | 0.59 | 0.92 | |
| PD6.F2 | R5 | >12.50 | <0.20 | >12.50 | <0.20 | 6.51 | |
| PD6.A9 | X4 | 7.75 | <0.20 | >12.50 | 0.57 | >12.50 | |
| PD6.C10 | X4 | 3.31 | 0.68 | >12.50 | 5.07 | 4.60 | |
| PD6.C7 | X4 | 0.78 | <0.20 | NDb | 6.12 | <0.20 | |
| PD6.D7 | X4 | >12.50 | <0.20 | 8.16 | 8.24 | 0.57 | |
| PD6.E8 | X4 | <0.20 | <0.20 | >12.50 | >12.50 | 0.74 | |
| PD6.F10 | X4 | 8.26 | <0.20 | >12.50 | 2.24 | 0.71 | |
| PR6.A10 | 3.5 | R5 | >12.50 | 6.92 | 0.18 | 3.68 | >12.50 |
| PR6.A2 | R5 | 0.22 | 3.64 | <0.20 | 0.70 | 0.62 | |
| PR6.A7 | R5 | 8.63 | 3.34 | 1.27 | 0.94 | 0.38 | |
| PR6.E10 | X4 | 1.38 | <0.20 | <0.20 | 0.30 | 3.41 | |
| PR6.E6 | X4 | 0.29 | 0.28 | ND | <0.20 | <0.20 | |
| PR6.F3 | X4 | >12.50 | 0.18 | >12.50 | ND | >12.50 | |
| PR6.G8 | X4 | 4.58 | 0.30 | 0.20 | 0.39 | ND | |
| PR6.11.A5 | 9 | X4 | >12.50 | 0.27 | <0.20 | 0.99 | 0.97 |
| PR6.11.B3 | X4 | 12.00 | 0.40 | 7.20 | 0.65 | 5.61 | |
| PR6.11.C1 | X4 | 8.99 | 1.96 | 0.62 | 0.27 | 4.57 | |
| PR6.12.A4 | 11 | R5 | >12.50 | 11.64 | <0.20 | <0.20 | <0.20 |
| PR6.12.C6 | R5 | >12.50 | 6.73 | >12.50 | <0.20 | 1.04 | |
| PR6.12.D4 | R5 | 11.78 | 4.69 | ND | 2.12 | 6.37 | |
a
D, donor; R, recipient; P, parenteral.
b
ND, not determined.