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. 2007 May 30;81(16):8692–8706. doi: 10.1128/JVI.00527-07

TABLE 2.

Gene expression during SARS disease course

Gene product designation (by function or type) Name/description Unigene designation Gene expressiona
Precrisis group
Precrisis steroid-treated group
Crisis-phase group
Mean ratio P Mean ratio P Mean ratio P
Antigen presentation
    HLA-B Major histocompatibility complex I-B Hs.77961 −0.63 0.046 −1.39 0.002 −0.88 0.001
    HLA-C Major histocompatibility complex I-C Hs.449621 −0.59 0.003 −0.95 0.008 NS
    HLA-DMB Major histocompatibility complex II-DM beta Hs.351279 −1.01 <0.001 −1.03 <0.001 −0.86 <0.001
    HLA-DPA1 Major histocompatibility complex II-DP alpha 1 Hs.347270 −1.40 <0.001 −1.67 <0.001 −1.80 <0.001
    HLA-DPB1 Major histocompatibility complex II-DP beta 1 Hs.485130 −1.28 0.002 −1.44 0.03 −1.88 0.003
    HLA-DQA1 Major histocompatibility complex II-DQ alpha 1 Hs.198253 NS NS −1.19 0.005
    HLA-DQB1 Major histocompatibility complex II-DQ beta 1 Hs.409934 −0.92 0.030 −1.04 0.001 −1.39 0.011
    HLA-DRB3 Major histocompatibility complex II-DR beta 3 Hs.308026 NS NS −1.18 0.004
    HLA-E Major histocompatibility complex I-E Hs.118354 −0.84 <0.001 −1.18 <0.001 −0.76 <0.001
Cell death
    BAG1 BCL2-associated athanogene protein Hs.377484 −1.11 <0.001 −1.61 <0.001 −1.10 <0.001
    BAG3 BCL2-associated athanogene 3 protein Hs.643507 −0.86 0.001 −1.18 0.006 −1.03 <0.001
    BAG4 BCL2-associated athanogene 4 protein Hs.194726 −1.07 0.02 −1.30 <0.001 −0.92 0.017
    BAG5 BCL2-associated athanogene 5 protein Hs.5443 −1.11 <0.001 −0.70 <0.001 −0.76 <0.001
    CD14 CD14 molecule Hs.163867 NS NS −0.83 0.001
Homeostasis
    MT1F Metallothionein 1F Hs.513626 1.04 <0.001 NS 0.49 0.011
    MT1G Metallothionein 1G Hs.433391 1.18 <0.001 NS 0.26 0.045
    MT2A Metallothionein 2A Hs.534330 1.19 <0.001 0.85 0.013 0.74 0.045
Immune response and host defense
    CXCL14 CXC chemokine ligand 14 Hs.483444 0.93 0.001 NS NS
    IGHG3 Ig heavy constant gamma 3 Hs.564623 −0.83 0.005 −1.56 0.005 −1.12 0.012
    SERPIN G1 Serpin peptidase inhibitor, clade G, member 1 Hs.384598 0.95 <0.001 NS 0.50 0.017
    SOD1 Superoxide dismutase 1, soluble Hs.443914 −1.10 <0.001 −1.15 0.009 −1.19 <0.001
    SOD2 Superoxide dismutase 2, mitochondrial Hs.487046 −1.16 <0.001 NS NS
    STAT6 Signal transducer and activator of transcription 6 Hs.524518 −1.77 <0.001 −1.66 <0.001 −1.30 <0.001
    TAP1 Ag peptide transporter 1 Hs.352018 NS NS −0.73 0.032
    VAV1 Vav 1 oncogene protein Hs.116237 −1.03 <0.001 −0.95 0.02 −1.09 <0.001
    VAV2 Vav 2 oncogene protein Hs.369921 0.84 0.05 NS NS
Interferon-stimulated gene products
    CCL19 CC chemokine ligand 19 Hs.50002 −0.93 <0.001 −1.05 <0.001 −0.57 <0.001
    CCL2 CC chemokine ligand 2 Hs.303649 1.32 <0.001 0.72 <0.001 NS
    CIG5 Radical S-adenosyl methionine domain-containing 2 Hs.17518 1.65 <0.001 1.34 <0.001 0.37 0.049
    CSF2RA Colony-stimulating factor 2 receptor alpha Hs.520937 0.6 <0.001 0.53 0.004 0.51 <0.001
    IFIT3 IFN-induced protein with tetratricopeptide repeats 3 Hs.47338 0.85 0.001 NS NS
    IFITM1 IFN-induced transmembrane protein 1 Hs.458414 0.81 0.02 NS NS
    IFNGR1 IFN-γ receptor 1 Hs.520414 −0.62 0.013 NS NS
    MT1B Metallothionein 1B Hs.36102 1.53 <0.001 0.84 0.003 0.7 0.001
    MT1H Metallothionein 1H Hs.2667 1.21 <0.001 NS NS
    MXA Myxovirus resistance 1 Hs.517307 1.5 <0.001 1.17 <0.001 NS
    PBEF Pre-B-cell colony-enhancing factor Hs.239138 −1.48 <0.001 −1.02 0.022 NS
    PSME1 Proteasome activator subunit 1 Hs.75348 −0.94 <0.001 −1.14 <0.001 −1.02 <0.001
    SDC1 Syndecan 1 Hs.82109 1.24 0.006 NS NS
    SDCBP Syndecan binding protein (syntenin) Hs.200804 −1.18 <0.001 −1.17 0.013 −1.10 0.005
a

Gene expression ratios are F-tested by ANOVA against, and relative to, means for healthy controls (n = 10). The numbers of patients in the precrisis group, the precrisis group treated with steroids, and the crisis-phase SARS patient group were 17, 7, and 13, respectively. Mean gene expression values were considered biologically significant at 0.58 (upregulated 1.5-fold) and −0.58 (downregulated 1.5-fold). Boldface indicates upregulated genes (≥1.5-fold). Boldface with underlining indicates downregulated genes (≥1.5-fold). NS, nonsignificant.