TABLE 4.

Association between HIV-specific IFN-γ SFC frequencies and HIV-1 plasma viral load in 19 HIV-1/2 dually infected subjects

Peptide	IFN-γ SFC frequency
	Univariable regression		Multivariable regressiona
	Log10 plasma HIV-1 RNA	P	Log10 plasma HIV-1 RNA	P
HIV-1
Env	0.04	0.92	0.02	0.94
Gag	−0.36	0.21	−0.32	0.21
Nef	−0.03	0.91	−0.06	0.79
Tat	−0.22	0.63	−0.04	0.93
Any HIV-1 peptide	−0.29	0.44	0.14	0.68
HIV-2
Env	−0.59	0.15	−0.34	0.38
Gag	−0.52	0.06	−0.43	0.07
Nefb	NAc	NA	NA	NA
Tat	0.55	0.58	0.68	0.39
Any HIV-2 peptide	−0.50	0.09	−0.33	0.19

^aValues were adjusted for CD4⁺ cell counts, study site, and gender.

^bNone of the dually infected subjects had HIV-2 Nef responses.

^cNA, not applicable.