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. 2007 Jun 27;81(17):9408–9418. doi: 10.1128/JVI.00707-07

FIG. 5.

FIG. 5.

Induction of high-quality HIV-1-specific CD4+ T cells and complete protection against surrogate virus challenge. The mice and the treatment groups (1 through 6) were the same as those described in the legend to Fig. 4A. (A) The leftmost panels summarize the data obtained for each cytokine and vaccination group. Data are presented as means ± SD (n, 4 to 5 mice). The middle panels demonstrate the gating for IFN-γ-, TNF-α-, and IL-2-producing CD4+ T cells as generated by group 6 for a cocktail of three MHC class II epitopes. The rightmost panels give the upper-right-quadrant data for trifunctional HIV-1-specific CD4+ T cells from individual mice (circles) and groups (bars). Data are presented as means ± SD (n, 4 to 5 mice). (B) Mice were either left naïve (1) or vaccinated with BCG.p (2), BCG.HIVA (3), pTHr.HIVA DNA (4), pTHr.HIVA DNA and BCG.p (5), or pTHr.HIVA and BCG.HIVA (6) and challenged with WR.HIVA. The WR.HIVA loads in ovaries were determined 4 days later. Data for individual mice (circles) and group means (bars; n, 4 to 5 mice) are shown.