FIG. 1.

Deduced amino acid sequences of variable domains of heavy (a) and light (b) chains of chimpanzee/human anti-A33 MAbs. Complementarity-determining regions (CDR1, CDR2, and CDR3) and framework regions (FWR1, FWR2, and FWR3) are indicated above the sequence alignment. Substitutions relative to 6C are expressed as single letters denoting amino acids. Dashes indicate identical residues, and asterisks denote the absence of corresponding residues relative to the longest sequence.