TABLE 4.
Tissue specificity of EV71(S1-3′) in the CNS of cynomolgus monkeys
| Tissue | Virus isolation (inflammation) for monkey no. [treatment]a:
|
|||||
|---|---|---|---|---|---|---|
| 4652 [EV71(S1-3′), day 4 p.i.] | 4699 [EV71(S1-3′), day 4 p.i.] | 4513b [EV71(S1-3′), day 10 p.i.] | 4514b [EV71(S1-3′), day 10 p.i.] | 4507c [EV71(BrCr-TR), day 6 p.i.] | 4508c [EV71(BrCr-TR), day 6 p.i.] | |
| Cerebrum | − (−) | − (−) | − (−) | − (+) | + (+) | + (+) |
| Midbrain | − (−) | − (−) | − (−) | − (+) | + (+) | + (+) |
| Pons | − (+) | − (−) | − (−) | − (+) | + (+) | + (+) |
| Cerebellum | − (−) | − (−) | − (−) | − (+) | + (+) | + (+) |
| Medulla | − (+) | − (−) | − (−) | − (+) | + (+) | + (+) |
| Cervical cord | + (+) (101.75) | − (−) | − (−) | − (+) | + (+) | + (+) |
| Lumbar cord [lesion score]d | + (+) (103.5) [0.9] | + (+) (103.0) [0.3] | − (−) [0.0] | + (+) [1.3] | + (+) [2.9] | + (+) [3.2] |
The virus isolation results are shown as positive or negative. The presence of inflammation in the tissues is shown in parentheses as positive or negative. The inoculated viruses and the day sacrificed are also indicated. The virus titer (CCID50) in 100 μl of the homogenate is shown, in parentheses following the isolation and inflammation results, for the samples collected from two monkeys, numbers 4652 and 4699.
Samples from monkeys numbers of 4513 and 4514 were collected in a previous study (5).
Data on monkeys inoculated with virulent EV71(BrCr-TR) (numbers 4507 and 4508) were adapted from a previous publication with the permission of the Society for General Microbiology (5).
The lesion score of the lumbar cord was determined for each monkey and is shown in brackets.