TABLE 5.
Tissue specificity of EV71(S1-3′) and EV71(BrCr-TR) in extraneural tissues of cynomolgus monkeys
| Tissue | Virus isolation (inflammation) for monkey no. [treatment]a:
|
|||
|---|---|---|---|---|
| 4652 [EV71(S1-3′), day 4 p.i.] | 4699 [EV71(S1-3′), day 4 p.i.] | 4507b [EV71(BrCR-TR), day 6 p.i.] | 4508b [EV71(BrCR-TR), day 6 p.i.] | |
| Tonsil | − (−) | − (−) | − (−) | − (−) |
| Heart | − (−) | − (−) | − (−) | − (−) |
| Lung | − (−) | − (−) | − (−) | − (−) |
| Liver | − (−) | − (−) | − (−) | − (−) |
| Spleen | − (−) | − (−) | + (−) | − (−) |
| Kidney | − (−) | + (+) (105.75) | + (−) | + (+) |
| Muscle | − (−) | − (−) | ND | ND |
| Deep cervical lymph node | + (−) (<100.5) | + (−) (102.5) | + (−) | + (−) |
| Dorsal root ganglion | + (−) (101.25) | − (−) (<100.5) | + (+) | + (+) |
a
The virus isolation results are shown as positive or negative. The presence of inflammation in the tissues is shown in parentheses as positive or negative. The inoculated viruses and the day sacrificed are also indicated. The virus titer (CCID50) in 100 μl of the homogenate is shown, in parentheses following the isolation and inflammation results, for the samples collected from two monkeys, numbers 4652 and 4699.
b
Samples of monkeys numbers 4507 and 4508 were collected in our previous study (5). ND, not determined.